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OBJECTIVE@#To explore the efficacy and safety of Zhuang medicine medicated thread moxibustion (ZMTM) on psoriasis vulgaris.@*METHODS@#A multicenter, randomized, parallel controlled clinical trial was designed. A total of 241 outpatients with psoriasis vulgaris were randomly divided into a control group (120 cases) and a treatment group (121 cases) using a central block randomization from June 2015 to May 2018. The control group was treated with Western medicines alone including pidotimod dispersible tablets, vitamin B compound tablets, and compound cod liver oil-zinc oxide ointment. The treatment group was treated with ZMTM every 2 days combined with Western medicines. The two groups received continuous intervention for 30 days. The primary outcome was Psoriasis Area and Severity Index (PASI), and the secondary outcomes included Itch Rating Scale, Dermatology Quality of Life Index (DLQI), Hamilton Anxiety Rating Scale (HAMA), as well as PASI response rate. Meanwhile, adverse events were evaluated during the whole clinical trial. Follow-up was carried out 30 days after treatment.@*RESULTS@#There were 5 cases of shedding in this trial. In intention-to-treat analysis, 236 cases were included and each group contained 118 cases. On the 30th and 60th days, PASI scores of patients in each group were significantly lower than that at baseline (P<0.01) and the PASI score reduction of the treatment group was greater than that of the control group (P<0.01). Itch Rating Scale, DLQI, and HAMA scale were decreased in both groups after treatment, and the treatment group showed a better therapeutic effect (P<0.01). The response rates of PASI 50 and 75 were significantly higher than those in the control group [81.4% (96/118), 43.2% (51/118) vs. 41.5% (49/118), 11.0% (13/118), respectively, P<0.05]. During follow-up, the improvements in scores of PASI, Itch Rating Scale, DLQI, and HAMA of the treatment group were significantly greater than those of the control group (P<0.01). The response rates of PASI 50 and 75 in the treatment group were significantly higher than those in the control group, respectively (both P<0.05). No obvious adverse reaction was found in either group.@*CONCLUSION@#ZMTM combined with Western medicines showed a better therapeutic effect in the treatment of psoriasis vulgaris without obvious adverse reaction. (Trial Registration No. ChiCTR-IOR-16008159).
Subject(s)
Humans , Moxibustion/adverse effects , Psoriasis/drug therapy , Quality of Life , Severity of Illness Index , Treatment OutcomeSubject(s)
Humans , Acupuncture , Acupuncture Points , Acupuncture Therapy , Eczema/therapy , MoxibustionABSTRACT
OBJECTIVE: To observe the effect of medicated thread moxibustion of Zhuang Minority medicine on helper T cell 17 (Th17)/ Interleukin-17F(IL-17F) signaling pathway in ulcerative colitis (UC) rats, so as to explore its mechanisms underlying improvement of UC. METHODS: Forty male SD rats were randomly divided into normal control, model, medication and medicated thread moxibustion (MTM) groups, with 10 rats in each group. The UC model was induced by free drinking of 4% dextran sulfate sodium (DSS) for 10 d. After successful modeling, rats of the medication group were treated by gavage of salazosulfapyridine (SASP). Medicated thread moxibustion was applied to unilateral "Tianshu" (ST25) and "Qihai" (CV6) alternatively for rats of the MTM group, once daily for 14 d. The body mass, stool shape, and fecal occult test were recorded and conducted daily to perform disease activity index (DAI) score. H．E. staining was used to display pathological changes of the colon tissue. The Th17 cells and IL-17F and retinoic acid related orphan receptor γ t (ROR-γt) in the colon tissue were detected by flow cytometry, and enzyme-linked immunosorbent assay (ELISA), respectively, and the expression levels of RORγt and IL-17F mRNA in colon tissue were detected by quantitive real-time PCR. RESULTS: After modeling, the DAI score, colonic Th17 percentage, RORγt and IL-17F contents, and RORγt and IL-17F mRNA expression were significantly increased in the model group in contrast to the normal control group (P0.05, except RORγt and IL-17F mRNA expression). H．E. staining showed disappearance of goblet cells, infiltration of a large number of inflammatory cells, exfoliation of the epithelial tissue and edema of colonic mucosal in rats of the model group, which was relatively milder in both medication and MTM groups. CONCLUSION: Medicated thread moxibustion of Zhuang Minority medicine can reduce the inflammatory damage of colon tissue in UC rats, which is associated with its effects in suppressing the expression of RORγt, production of Th17 cells, and secretion of pro-inflammatory factor IL-17F in colon tissue.
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Acupoint medicated catgut embedding therapy is a new type of acupuncture combined with medicine，which has great potential in the prevention and treatment of chronic diseases. This paper describes the clinical application of acupoint medicated catgut embedding in the treatment of common disease, medicated thread productionmethods and acupoints selection.To analyze the problems of the unclear mechanism, the lack of standardization of medicated thread production, the lag of the embedding tool, and the unclear adverse reaction. It is expected to promote the further development of acupoint medicated catgut embedding therapy by strengthening the mechanism of action, optimizing medicated catgut thread, rational design experiments, standardizing medicated thread production, innovating embedding tools, rational formulation, and optimizing acupoint selection.
Subject(s)
Humans , Acupuncture Points , Acupuncture Therapy , Catgut , Combined Modality TherapyABSTRACT
Objective To study the clinical effect of Zhuang medicine line point moxibustion in the treatment of psoriasis vulgaris.Methods 60 psoriasis vulgaris patients qualified subjects were randomly divided into observation group and control group.The control group was given routine treatment of psoriasis.The treatment group was given Zhuang medicine line points on the basis of the control group.The patients in two groups were treated for four courses.The clinical efficacy of the two groups were compared,and the changes of PASI score and DLQL score at different time periods were compared.Results The total effective rate of treatment group was 76.7%,which was higher than 50.0% in the control group (χ2 =3.125,P<0.05).After 2,3 and 4 courses of treatment,the PASI scores and DLQL scores between the observation group and the control group at the same time point had statistically significant differences (all P<0.05).Conclusion In this study,the use of Zhuang medicine line point moxibustion treatment for psoriasis vulgaris patients has significant curative effect,which can be used as the treatment for psoriasis vulgaris.
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Objective To observe the therapeutic effects of medicated thread moxibustion of traditional Zhuang nationality medicine combined with Shugan Jianpi Decoction for cirrhosis ascites. Methods Sixty patients with cirrhosis ascites were randomly divided into observation group and control group by random number method, 30 cases in each group. The treatment group received medicated thread moxibustion of traditional Zhuang nationality medicine combined with Shugan Jianpi Decoction and regular Western medicine; while control group only received regular Western medicine. Two weeks was a course of treatment. The liver function (ALT, AST, TBIL, ALB, A/G), ascites integral changes and improving time of main clinical symptoms (abdominal distension, pain, anorexia, fatigue) were observed. The clinical curative effects of two groups were evaluated with 3 months of follow-up. Results The liver function (ALT, AST, TBIL, ALB, A/G) in the treatment group after treatment was significantly improved, and the ascites integral decreased, which was better than the control group, with statistical significance (P<0.05). The improving time of main clinical symptoms in the treatment group was significantly shorter than the control group (P<0.05);The clinical effective rate was 90.00%(27/30) in the treatment group and 76.67% (23/30) in the control group, with statistical significance (P<0.05). Conclusion Medicated thread moxibustion of traditional Zhuang nationality medicine combined with Shugan Jianpi Decoction has good efficacy for cirrhosis ascites.
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The exploring,standardizing and summarizing of the medicated thread moxibustion ofethnic group are introduced. It is found that there are something deficiency needed to be improved about its system. Thus,we propose a few suggestions and supplements including the definition,the preparation and grasp of the threads,firing and moxibustion manipulation,its intensity of operation,the specification of the threads and moxibustion frequency. We hope that it will provide reference to the improvement of its system.
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This study was aimed to observe the effects of acupuncture combination with medicated thread moxibustion ofZhuang nationality medicine on neurotransmitters in rats with sleep deprivation. A total of 80 SPF grade healthy Wistar rats were randomly divided into the control group, model group, treatment group and diazepam group with 20 rats in each group. The establishment of insomnia model was through sleep deprivation in the model group, treatment group and diazepam group. Based on the treatment of the model group, the treatment group was treated by acupuncture combination with medicated thread moxibustion ofZhuang nationality medicine, once a day for continuous 14 days. Intragastric administration of diazepam according to 3 mg·kg-1 body weight was given in the diazepam group. While intragastric administration of the same volume normal saline was given to the control group once a day for continuous 14 days. And then, the levels of orexin, NE, 5-HT, CRH and ACTH were detected. The expressions of orexin mRNA and c-Fos were observed. The results showed that compared with the control group, the levels of orexin, ACTH, 5-HT, NE and CRH increased or obviously increased in the model group with significant difference (P < 0.05, orP< 0.01). The expressions of orexin mRNA and c-Fos in the model group were increased or obviously increased with significant difference (P < 0.05, orP< 0.01). Compared with the model group, the levels of orexin, ACTH, 5-HT, NE and CRH reduced or obviously reduced with significant difference in the treatment group (P < 0.05, orP < 0.01). The expressions of orexin mRNA and c-Fos were reduced or obviously reduced with significant difference in the treatment group (P <0.05, orP < 0.01). It was concluded that acupuncture combination with medicated thread moxibustion ofZhuang nationality medicine took an effect on the treatment of insomnia by mediating neurotransmitters associated with hypothalamic-pituitary-adrenal axis (HPA axis) through orexin, which was probably related with its therapeutic mechanism.
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Objective To observe the therapeutic effect of Jin’s three-needle therapy plus medicated thread moxibustion for shoulder-hand syndrome at phaseⅠ. Methods By simple randomized controlled method, sixty qualified patients were randomized into observation group (N=32) and control group (N=28) . The observation group was given Jin’s three-needle therapy plus medicated thread moxibustion, and the control group was given conventional acupuncture therapy. Treatment was performed once a day for the two groups, 5 continuous times per week, and one course covered 3 weeks. At the end of the treatment, therapeutic effect, simplified Fugl-Meyer scores for upper limb motor ability, and pain visual analog scale ( VAS) scores were compared between the two groups. Results (1) The total effective rate was 93.7% in the observation group and was 82.1% in the control group, the difference being significant ( P<0.05). ( 2) Fugl-Meyer scores were improved in the two groups after treatment (P<0.05 or P<0.01), and the improvement of the observation group was superior to that of the control group ( P<0.05). ( 3) The results of VAS scoring showed that the pain in the upper limb was much relieved in both groups after treatment ( P<0.05 or P<0.01) , and the relief of pain was more obvious in the observation group ( P<0.05). Conclusion Jin’s three-needle therapy plus medicated thread moxibustion exerts certain therapeutic effect for shoulder-hand syndrome at phaseⅠ.